Nick Cushing, manager of Manchester City, will leave the Women's Super League club after more than six years in office.
The 35-year-old is to take on the position of deputy manager for the New York City men's team at MLS in the USA.
His last game as Manchester City boss will be at home on 2 February against WSL champions Arsenal.
Since taking office in 2013, Cushing has won six major trophies, including the WSL title in 2016 and two FA Cups.
Cushing, who said the decision to join Ronny Deila's New York City was not "lightly" made, has been the club's only manager in the WSL era since they rose to the top in 2014.
"We had an amazing six and a half seasons and I really enjoyed working with everyone. I'll be very emotional when I leave," he told the Manchester City website.
"Working with New York City and Ronny (Deila) is a great opportunity and I'm really looking forward to working at the MLS."
"He is missing, but everyone is excited about him"
During his time as a city boss, he accompanied her rise to a dominant force in the English game.
Over the past four seasons, they have each qualified for the Women's Champions League. However, after reaching the semi-finals in their first two European campaigns, they failed to get past the last eight seasons of the competition.
After leading City to her first championship title, he was shortlisted for the English women, but withdrew from the process before Phil Neville handed over the role.
He will leave City with a remaining contract term of 18 months after signing a three and a half year contract in December 2017.
City is second in the WSL table after eleven games, just three points behind leaders Arsenal.
His planned departure after visiting the Gunners in February at the Academy Stadium means that he will remain responsible for five more games, including the four-round game of the Women's FA Cup against local rival Manchester United.
Cushing's assistant, former Tranmere and Republic of Ireland midfielder Alan Mahon, will take over as interim city chief.
The move for Cushing while going for men and across the Atlantic means that he continues to work for the City Football Group, which includes Manchester City, the New York Club and a number of other teams worldwide.
"He's missing, but everyone here is excited about him and this exciting new company in the City Football Group," said Gavin Makel, director of women's football in Manchester City.
Tom Garry, BBC Sport
Cushing was one of the most successful managers in the modern era of women's football. He has won the FA Cup at Wembley twice in the past three years and has led City in four of the last five League Cup finals.
His team has not left the first two spots in the WSL since 2014 and, together with Arsenal and Chelsea, has dominated in five successive domestic campaigns.
Cushing has not only got used to winning silverware, but has also earned a reputation for promoting young talent from within the country.
He named a purely British XI, nine of whom were English, for a 2-0 win over Chelsea in September 2016, which earned the club its first WSL title.
He will be disappointed forever that he has not reached a Champions League final – he has narrowly lost to Lyon in the last four games in 2016-17 and 2017-18, before going through the second round by Spanish giant Atletico Madrid retired last two campaigns.
Nevertheless, one of his most important successes will be the wealth of English talent that the club can now boast of. This has rarely been emphasized better than at the FA Cup final at Wembley, when all three Manchester City goalscorers triumphed 3-0.The victory over West Ham United – Keira Walsh, Georgia Stanway and Lauren Hemp – was English and younger than 22 years.
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