Manchester City's goal scorer did a hat-trick against Aston Villa on Sunday to outshine Thierry Henry as the division's top international scorer.
The hat-trick at Villa Park was Aguero's twelfth in the Premier League, which also surpassed Alan Shearer's previous hat-trick record.
Aguero left the field with a big smile on his face and the match ball under his arm, a souvenir of his record hat trick.
The Premier League has brought foreign talent to the English coast since its inception, and Aguero is now certainly one of the best of them.
"Incredible person, incredible player"
The 31-year-old moved from the Spanish club Atletico Madrid to Manchester City in 2011 and quickly established himself as a great talent and strong scorer.
"He's one of the most incredible players I've seen in this league," said Manchester City manager Pep Guardiola.
"He is an incredible person. He always has to be fit. He likes to play football and in the last third he has the goal in mind."
Aguero is the city's top scorer with 249 goals – perhaps the most important of all is his late goal against the Queens Park Rangers for the club's first Premier League title against rival Manchester City in 2012.
Alan Shearer is the top scorer in the league with 260 goals. When asked if he is now pursuing this record, Aguero smiled: "I'll try … There are too many goals, but I'll try."
Manchester City may be lagging behind Liverpool in defending its title – the champions are now 14 points behind the second – but it was an unscrupulous 6-1 win at Villa Park, with the home team falling into the relegation zone.
Riyad Mahrez gave City a brilliant single goal in the 17th minute as he passed two defenders and shot the ball into the net.
Just six minutes later, Mahrez added a second when he found the ball at his feet after messily defending himself against Villa.
Kevin De Bruyne was at the center of City's last two goals when he first set up Aguero and then Gabriel Jesus. Aguero released a breathtaking goal in the top corner before Jesus De Bruyne's perfect pass.
The champions' relentless striker swing continued after the break when Aguero scored again and pushed David Silva's pass home before scoring a third goal in the 80th minute.
Mahrez also paid tribute to his team-mate Aguero: "The statistics speak for themselves. He is a legend for this club and for the Premier League.
"He shows it week after week. He has a lot of quality but he doesn't need a lot of chances and that shows what a great striker he is."